QUANTITATIVE RENAL SCINTIGRAPHIC DETERMINATION OF EFFECTIVE RENAL PLASMA-FLOW IN DOGS WITH NORMAL AND ABNORMAL RENAL-FUNCTION, USING TC-99M-MERCAPTOACETYLTRIGLYCINE

Effective renal plasma now (ERPF) was evaluated, using the measurement of p-aminohippurate clearance (CL(PAH)) and quantitative renal scinti graphy (QRS) with Tc-99m-mercaptoacetyltriglycine (Tc-99m-MAG3). The C L(PAH) and QRS determinations were made in 6 dogs: 2 determinations fo r each dog before, and 1 determination after induction of renal failur e by administration of amphotericin B. Least-squares regression analys is was used to derive an equation to estimate ERPF from QRS data. The results indicated that QRS, using Tc-99m-MAG3, correlated reasonably w ell (r = 0.82, P < 0.001) with ERPF determined from the CL(PAH) value. The right kidney contributed 53.3% of global ERPF (P = 0.002). Hepato biliary excretion of Tc-99m-MAG3 was variable within each dog. There w as not a consistent pattern with respect to time or renal function. Al l dogs had nausea or emesis, or both, after IV administration of Tc-99 m-MAG3. The QRS method with Tc-99m-MAG3 provides an adequate means to estimate ERPF in healthy dogs and dogs with renal failure.