Sg. Krohne, EFFECT OF TOPICALLY APPLIED 2-PERCENT PILOCARPINE AND 0.25-PERCENT DEMECARIUM BROMIDE ON BLOOD-AQUEOUS BARRIER PERMEABILITY IN DOGS, American journal of veterinary research, 55(12), 1994, pp. 1729-1733
The effect of topically applied 2% pilocarpine and 0.25% demecarium br
omide on aqueous humor flare was evaluated while treating normal eyes
of dogs 3 times daily for 8 days. Fifteen clinically normal Beagles we
re allotted to 2 drug treatment groups, and flare was measured, using
laser flaremetry. Pilocarpine caused an increase of flare to 167 photo
n counts (pc)/ms at 7 hours, compared with the nontreated control eye
mean value 3.7 pc/ms. By 31 hours, flare had decreased to 70 pc/ms wit
h 3 daily topical treatments. By 55 hours, the flare measurement was i
n the normal range. Intraocular pressure (IOP) decreased in the treate
d eyes, compared with the nontreated eyes, and maximal decrease in IOP
was observed at the same time as maximal flare. Demecarium induced a
similar increase in flare and decrease in IOP, with peak effect seen a
t 31 hours. At that time, the flaremetry result was 28 pc/ms, compared
with 3.4 pc/ms in the nontreated control eyes. After 8 days of 3 time
s daily treatment, flare values had returned to normal in eyes of dogs
in both treatment groups. The transient increase in aqueous humor pro
tein concentration did not result in ocular or visual damage, and long
-term changes were not seen. The amount of flare increase attributable
to topical. application of pilocarpine was greater than the increase
in human eyes when measured by use of laser flaremetry.