THERAPY OF MUCOSITIS DURING ADMINISTRATIO N OF CHEMOTHERAPY WITH VITAMIN-E

Mucositis represents one of the most frequent complications during che motherapy or radiotherapy. Few studies have showed effective preventio n against mucositis in this setting. In this randomized study, we test ed the efficacy of vitamin E in the treatment of chemotherapy-induced mucositis. Twenty patients with malignant haemopathies were included; 19 patients were evaluable for the prevention of mucositis. Ten patien ts were treated with induction therapy for acute myelogenous leukaemia and 9 were treated with intensive therapy followed by autologous bone marrow transplantation. The severity of mucositis was evaluated accor ding to World Health Organization classification. Our results showed t hat vitamin E may be of therapeutical value in the prevention of mucos itis especially during induction therapy for acute myelogenous leukaem ia.