AFRICAN HISTOPLASMOSIS - CLINICAL AND THE RAPEUTIC ASPECTS, RELATION WITH AIDS - 4 CASES

The authors report 4 cases of African histoplasmosis in Zairans. The d iagnostic was based ou cutaneous (4 patients), bones (3), lymph-nodes (2), and bowel-localizations (1) and was confirmed by the presence of Histoplasma duboisiis yeasts in cutaneous biopsy (4 patients), in pus of abscess or cutaneous lesions (3) and in stools (1). Two HIV seroneg atives patients had a good outcome with amphotericin B. One patient di ed without any treatment. One HIV 1 and HTLV1 seropositive patient had successful short-term outcome with ketoconazole. Seven others cases o f association between African histoplasmosis and AIDS are noted in the litterature. They suggest the opportunistic nature of this deep mycos is.