Sa. Tobet et al., MIGRATION OF NEURONS CONTAINING GONADOTROPIN-RELEASING-HORMONE (GNRH)IN SLICES FROM EMBRYONIC NASAL COMPARTMENT AND FOREBRAIN, Developmental brain research, 97(2), 1996, pp. 287-292
During development, neurons containing gonadotropin-releasing hormone
traverse fiber bundles in the nose, cross into the brain, and move thr
ough a maze of glial and axonal fibers. To test whether GnRH neurons u
tilize cues intrinsic to their migration route to traverse the nasal/b
rain boundary, tissue slices that maintain connections between the for
ebrain and nasal compartment were prepared from mouse embryos. Cell mi
gration between the nasal and brain compartments was evident based on
changes in cell positions after successive days in vitro.