CARDIOTONIC FLAVONOIDS FROM CITRUS PLANTS (RUTACEAE)

Authors
ITOIGAWA M TAKEYA K FURUKAWA H
Citation
M. Itoigawa et al., CARDIOTONIC FLAVONOIDS FROM CITRUS PLANTS (RUTACEAE), Biological & pharmaceutical bulletin, 17(11), 1994, pp. 1519-1521
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
17
Issue
11
Year of publication
1994
Pages
1519 - 1521
Database
ISI
SICI code
0918-6158(1994)17:11<1519:CFFCP(>2.0.ZU;2-F
Abstract
Two flavonoids, 3,5,6,7,8,3',4'-heptamethoxyflavone (HEPTA) and natsud aidain isolated from Citrus plants (Rutaceae), produced a positive ino tropic effect (PIE) on guinea-pig papillary muscle. Natsudaidain (pD(2 ) 4.98+/-0.07) was more potent than HEPTA (pD(2) 4.33+/-0.08), but the maximum PIE of HEPTA was greater than that of natsudaidain. The PIE o f HEPTA was completely inhibited by reserpinization of the guinea pig, and partially inhibited by metoprolol and carbachol. The carbachol in hibition was omitted by atropine. The mechanism of PIE of HEPTA is acc ounted for catecholamine release from cardiac tissue.