ENHANCEMENT OF THE INTESTINAL-ABSORPTION OF A CYCLOSPORINE DERIVATIVEBY MILK-FAT GLOBULE-MEMBRANE

Authors
SATO H LIU HX ADACHI I UENO M LEMAIRE M HORIKOSHI I
Citation
H. Sato et al., ENHANCEMENT OF THE INTESTINAL-ABSORPTION OF A CYCLOSPORINE DERIVATIVEBY MILK-FAT GLOBULE-MEMBRANE, Biological & pharmaceutical bulletin, 17(11), 1994, pp. 1526-1528
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
17
Issue
11
Year of publication
1994
Pages
1526 - 1528
Database
ISI
SICI code
0918-6158(1994)17:11<1526:EOTIOA>2.0.ZU;2-X
Abstract
A cyclosporine derivative, dihydrocyclosporine D, was used for the eva luation of milk fat globule membrane (MFGM) as an emulsifier of lipoph ilic cyclopeptides. As compared with olive oil formulation, MFGM emuls ion significantly enhanced the blood and lymphatic fluid concentration s of the cyclosporine derivative after intraduodenal dosing in rats. T hus, it was suggested that MFGM can be used as an intestinal absorptio n enhancer of cyclosporines.