DIFFERENTIAL-PULSE POLAROGRAPHIC-DETERMINATION OF OMEPRAZOLE IN PHARMACEUTICAL PREPARATIONS

Authors
OZALTIN N TEMIZER A
Citation
N. Ozaltin et A. Temizer, DIFFERENTIAL-PULSE POLAROGRAPHIC-DETERMINATION OF OMEPRAZOLE IN PHARMACEUTICAL PREPARATIONS, Electroanalysis, 6(9), 1994, pp. 799-803
Citations number
11
Categorie Soggetti
Chemistry Analytical
Journal title
Electroanalysis → ACNP
ISSN journal
10400397
Volume
6
Issue
9
Year of publication
1994
Pages
799 - 803
Database
ISI
SICI code
1040-0397(1994)6:9<799:DPOOIP>2.0.ZU;2-5
Abstract
A new electroanalytical method was developed for the analysis of omepr azole. Various polarographic techniques and supporting electrolytes we re examined. Best results were obtained with differential pulse polaro graphy (DPP) in berate buffer (pH 9.0) solution. Linear response was o bserved from 2.0 x 10(-7) M to 2.0 x 10(-5) M. The peak potential was observed at -1.28 V (vs. Ag/AgCl). The developed method was applied to two different commercial hard gelatin capsules, containing enteric-co ated granules, preparations. The relative standard deviations were fou nd to be 3.04% (brand A) and 2.88% (brand B).