SUPPRESSION OF SPLENIC ENZYME-ACTIVITIES BY ADMINISTRATION OF AMINOPEPTIDASE-N (CD13) INHIBITORS - RELATIONSHIP BETWEEN ACTIONS IN-VIVO ANDIN-VITRO

Authors
KOCHA T OHTSUKA E FUNAHASHI T FUKUDA T AOYAGI T
Citation
T. Kocha et al., SUPPRESSION OF SPLENIC ENZYME-ACTIVITIES BY ADMINISTRATION OF AMINOPEPTIDASE-N (CD13) INHIBITORS - RELATIONSHIP BETWEEN ACTIONS IN-VIVO ANDIN-VITRO, Journal of enzyme inhibition, 8(3), 1994, pp. 187-195
Citations number
32
Categorie Soggetti
Biology
Journal title
Journal of enzyme inhibition → ACNP
ISSN journal
87555093
Volume
8
Issue
3
Year of publication
1994
Pages
187 - 195
Database
ISI
SICI code
8755-5093(1994)8:3<187:SOSEBA>2.0.ZU;2-T
Abstract
The enzymatic changes in murine spleen caused by the administration fo r 20 successive days of various inhibitors of aminopeptidase N (leucoc yte antigen CD13) have been compared. When compared with the control ( saline), most of the inhibitors significantly suppressed splenic enzym e activities including those of ectoenzymes. A multivariate study indi cated that the in vivo effects of the inhibitors were closely related to their inhibitory actions in vitro.