This retrospective study describes the effect of smoking on initial fi
xture failure before functional loading with fixed prosthetic restorat
ions. Of 208 installed Branemark fixtures in the mandible, only 1 fail
ed (0.5%), and no detrimental effect of smoking on fixture survival co
uld be detected. In the maxilla, 10/244 fixtures failed (4%); 7/78 fix
tures failed in smokers and 3/166 in nonsmokers. The failure rate befo
re loading was 9% in smokers versus 1% in nonsmokers and was statistic
ally significant, despite the fact that bone quality in both groups wa
s comparable. Failed fixtures occurred in 31% of the smokers, despite
often excellent bone quality, long fixture length or good initial stab
ility. Only 4% of the nonsmokers had failures, in most cases related t
o poor bone quality. It is concluded that smoking is a significant alt
hough not the only important factor in the failure of implants prior t
o functional loading. Prospective studies are needed to assess the ris
k of implant failure in conjunction with smoking. In the mean time, pa
tients should be informed of the adverse effect of smoking.