ANTILEUKEMIC PROPERTIES OF 12-HYDROXYDAPHNETOXIN DERIVATIVES

Authors
BAXTER RL ZIEGLER MF
Citation
Rl. Baxter et Mf. Ziegler, ANTILEUKEMIC PROPERTIES OF 12-HYDROXYDAPHNETOXIN DERIVATIVES, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2649-2652
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
22
Year of publication
1994
Pages
2649 - 2652
Database
ISI
SICI code
0960-894X(1994)4:22<2649:APO1D>2.0.ZU;2-X
Abstract
A number of 12-acyl derivatives of 12-hydroxydaphnetoxin, 15,16-dihydr o-12-hydroxydaphnetoxin, 1,2,15,16,-tetrahydro-12-hydroxydaphnetoxin a nd their 5,20 acetonides were prepared and their activities determined against murine P388 lymphocytic leukaemia. The saturated esters show reduced activity compared with the natural products 2-5.