Sv. Patil et al., SYNTHESES AND PROPERTIES OF OLIGOTHYMIDYLATE ANALOGS CONTAINING STEREOREGULATED PHOSPHOROTHIOATE AND PHOSPHODIESTER LINKAGES IN AN ALTERNATING MANNER, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2663-2666
Syntheses of decadeoxythymidylates containing stereoregulated phosphor
othioate and phosphodiester linkages in an alternating manner starting
from preseparated diastereochemically pure phosphorothioate dimers ar
e described. Hybridization of these modified oligonucleotides with the
complementary sequence has been investigated.