SYNTHESES AND PROPERTIES OF OLIGOTHYMIDYLATE ANALOGS CONTAINING STEREOREGULATED PHOSPHOROTHIOATE AND PHOSPHODIESTER LINKAGES IN AN ALTERNATING MANNER

Authors
PATIL SV MANE RB SALUNKHE MM
Citation
Sv. Patil et al., SYNTHESES AND PROPERTIES OF OLIGOTHYMIDYLATE ANALOGS CONTAINING STEREOREGULATED PHOSPHOROTHIOATE AND PHOSPHODIESTER LINKAGES IN AN ALTERNATING MANNER, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2663-2666
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
22
Year of publication
1994
Pages
2663 - 2666
Database
ISI
SICI code
0960-894X(1994)4:22<2663:SAPOOA>2.0.ZU;2-A
Abstract
Syntheses of decadeoxythymidylates containing stereoregulated phosphor othioate and phosphodiester linkages in an alternating manner starting from preseparated diastereochemically pure phosphorothioate dimers ar e described. Hybridization of these modified oligonucleotides with the complementary sequence has been investigated.