THE SQUALESTATINS - EFFECTS OF CHANGES AT THE ALLYLIC CENTER IN THE C1 SIDE-CHAIN

Authors
LESTER MG EVANS GL HENSON RA PROCOPIOU PA SAREEN M SNOWDEN MA SPOONER SJ SRIKANTHA AAP WATSON NS
Citation
Mg. Lester et al., THE SQUALESTATINS - EFFECTS OF CHANGES AT THE ALLYLIC CENTER IN THE C1 SIDE-CHAIN, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2683-2688
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
22
Year of publication
1994
Pages
2683 - 2688
Database
ISI
SICI code
0960-894X(1994)4:22<2683:TS-EOC>2.0.ZU;2-#
Abstract
The C4' acetoxy group in squalestatin 2a has been replaced by alkoxy, acyloxy and acetamido groups. The ethers 5b, 5c, 5e and 5g retain SQS inhibitory activity equivalent to that of 2a and are metabolically mor e stable. Ah other compounds tested are significantly less active.