STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE NON-PEPTIDYL GROWTH-HORMONE SECRETAGOGUE L-692,429

Authors
OK D SCHOEN WR HODGES P DEVITA RJ BROWN JE CHENG K CHAN WWS BUTLER BS SMITH RG FISHER MH WYVRATT MJ
Citation
D. Ok et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE NON-PEPTIDYL GROWTH-HORMONE SECRETAGOGUE L-692,429, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2709-2714
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
22
Year of publication
1994
Pages
2709 - 2714
Database
ISI
SICI code
0960-894X(1994)4:22<2709:SOTNGS>2.0.ZU;2-6
Abstract
Systematic investigation of the amino acid sidechain of L-692,429, the prototype of a novel class of benzolactam growth hormone (GH) secreta gogues, has led to the preparation of L-692,585, a 2(R)hydroxypropyl a mino analog, which is twenty times more potent in vitro than L-692,429 . Additional amino modifications reported here further define the stru cture-activity profile for L-692,429.