DUAL INHIBITION OF NEUTRAL ENDOPEPTIDASE AND ANGIOTENSIN-CONVERTING ENZYME BY N-PHOSPHONOMETHYL AND N-CARBOXYALKYL DIPEPTIDES

Authors
DELOMBAERT S TAN J STAMFORD LJ SAKANE Y BERRY C GHAI RD
Citation
S. Delombaert et al., DUAL INHIBITION OF NEUTRAL ENDOPEPTIDASE AND ANGIOTENSIN-CONVERTING ENZYME BY N-PHOSPHONOMETHYL AND N-CARBOXYALKYL DIPEPTIDES, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2715-2720
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
22
Year of publication
1994
Pages
2715 - 2720
Database
ISI
SICI code
0960-894X(1994)4:22<2715:DIONEA>2.0.ZU;2-R
Abstract
Structural modifications have been performed on the selective a-amino phosphonic acid NEP inhibitor CGS 24592, to achieve dual ACE/NEP inhib ition in vitro. -Phosphonomethyl-valyl-(S)-(4-phenyl)phenylalanine (19 ) is representative of a new type of phosphorus-containing ACE/NEP inh ibitors, approaching the in vitro potency of the sulfhydryl ACE inhibi tor captopril and the NEP inhibitor thiorphan.