TBE UNIQUE DNA CUTTING SEQUENCE SPECIFICITY OF A ,N-DIMETHYL-2-AMINOETHYL)AMINO-1,10-PHENANTHROLINE AND ITS 9-AMINOACRIDINE CONJUGATE

Authors
CHIU FCK BROWNLEE RTC MITCHELL K PHILLIPS DR
Citation
Fck. Chiu et al., TBE UNIQUE DNA CUTTING SEQUENCE SPECIFICITY OF A ,N-DIMETHYL-2-AMINOETHYL)AMINO-1,10-PHENANTHROLINE AND ITS 9-AMINOACRIDINE CONJUGATE, Bioorganic & medicinal chemistry letters, 4(22), 1994, pp. 2721-2726
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
22
Year of publication
1994
Pages
2721 - 2726
Database
ISI
SICI code
0960-894X(1994)4:22<2721:TUDCSS>2.0.ZU;2-Q
Abstract
A 1,10-phenanthroline with a 3-carboxamide and a cationic side chain a t C4 shows a highly sequence specific DNA cutting activity at 5'-TTAG sites. Conjugation with an 9-aminoacridine produced an additional clea vage site at 5'-TTAC. A binding model involving a 1:I:1 phenanthroline -copper-DNA complex is proposed based on the copper chelation chemistr y of several phenanthroline derivatives.