INHIBITION OF CAFFEINE METABOLISM BY CIPROFLOXACIN IN CHILDREN WITH CYSTIC-FIBROSIS AS MEASURED BY THE CAFFEINE BREATH TEST

Authors
PARKER AC PRESTON T HEAF D KITTERINGHAM NR CHOONARA I
Citation
Ac. Parker et al., INHIBITION OF CAFFEINE METABOLISM BY CIPROFLOXACIN IN CHILDREN WITH CYSTIC-FIBROSIS AS MEASURED BY THE CAFFEINE BREATH TEST, British journal of clinical pharmacology, 38(6), 1994, pp. 573-576
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British journal of clinical pharmacology → ACNP
ISSN journal
03065251
Volume
38
Issue
6
Year of publication
1994
Pages
573 - 576
Database
ISI
SICI code
0306-5251(1994)38:6<573:IOCMBC>2.0.ZU;2-M
Abstract
The caffeine breath test was carried out in six children with cystic f ibrosis, before and during a course of ciprofloxacin. There was a sign ificant decrease in the 2 h cumulative labelled CO2 exhaled during cip rofloxacin treatment, mean difference (s.d.) -5.2(3.3)%, P < 0.02. The results suggest an inhibition of 3-N-demethylation of caffeine (CYP1A 2 enzyme activity) by ciprofloxacin. Ciprofloxacin may cause significa nt drug interactions in children with cystic fibrosis. The caffeine br eath test can be used to study drug interactions involving CYP1A2 in c hildren.