HOW CELLS KNOW THEY ARE IN G(1) OR G(2)

Authors
OCONNELL MJ NURSE P
Citation
Mj. Oconnell et P. Nurse, HOW CELLS KNOW THEY ARE IN G(1) OR G(2), Current opinion in cell biology, 6(6), 1994, pp. 867-871
Citations number
41
Categorie Soggetti
Cytology & Histology
Journal title
Current opinion in cell biology → ACNP
ISSN journal
09550674
Volume
6
Issue
6
Year of publication
1994
Pages
867 - 871
Database
ISI
SICI code
0955-0674(1994)6:6<867:HCKTAI>2.0.ZU;2-M
Abstract
How does a cell know if it's in G(1) or G(2) and should proceed to S p hase or mitosis! This is a restatement of the question of how a cell e nsures mitosis is dependent upon S phase, and S phase is dependent upo n mitosis. Several gene products have been identified which play impor tant roles in maintaining these interdependencies. Central to these co ntrols are oscillations between different complexes of cyclins and cyc lin-dependent kinases.