EFFECTIVE ENANTIOSELECTIVE APPROACH TO ALPHA-AMINOALKYLACRYLIC ACID-DERIVATIVES VIA A SYNTHETIC EQUIVALENT OF AN ASYMMETRIC BAYLIS-HILLMAN REACTION - APPLICATION TO THE SYNTHESIS OF 2 C-2' HYDROXYMETHYL ANALOGS OF DOCETAXEL

Authors
GENISSON Y MASSARDIER C GAUTIERLUNEAU I GREENE AE
Citation
Y. Genisson et al., EFFECTIVE ENANTIOSELECTIVE APPROACH TO ALPHA-AMINOALKYLACRYLIC ACID-DERIVATIVES VIA A SYNTHETIC EQUIVALENT OF AN ASYMMETRIC BAYLIS-HILLMAN REACTION - APPLICATION TO THE SYNTHESIS OF 2 C-2' HYDROXYMETHYL ANALOGS OF DOCETAXEL, Journal of the Chemical Society. Perkin transactions. I, (24), 1996, pp. 2869-2872
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
24
Year of publication
1996
Pages
2869 - 2872
Database
ISI
SICI code
0300-922X(1996):24<2869:EEATAA>2.0.ZU;2-G
Abstract
Two C-2' hydroxymethyl analogues of docetaxel have been synthesized fr om 10-desacetyl baccatin III and enantiopure (3S)-3-(N-tert-butoxycarb onylamino)-2-methylene-3- phenylpropanoic acid; the latter was prepare d vip the use of a new method, which is discussed, as is the biologica l evaluation of the two new analogues.