PLACE CONDITIONING WITH COCAINE AND THE DOPAMINE UPTAKE INHIBITOR GBR12783

THE rewarding and locomotor effects of the specific dopamine uptake in hibitor GBR12783 (2.5-20 mg kg(-1) i.p.) were compared with those of c ocaine. For drugs, all doses produced a conditioned place preference ( CPP), even the dose of 2.5 mg kg(-1), which did not modify the locomot or activity. Despite an equivalent locomotor stimulation, the magnitud e of CPP induced by cocaine (10 mg kg(-1)) was greater than that induc ed by the same dose of GBR12783. This confirms the involvement of dopa mine uptake inhibition in reward, but underlines differences in relati ve efficacies in rewarding and motor effects of both drugs and suggest s that these two properties are, at least in pare, separable anatomica lly or functionally.