UNILATERAL DEFICITS INDUCED IN RATS BY MPP(-TERMINAL PEPTIDE FRAGMENTOF DOPAMINE-RELEASING PROTEIN() ARE MARKEDLY REDUCED BY AN N)

Authors
PHELPS SM RAMIREZ VD
Citation
Sm. Phelps et Vd. Ramirez, UNILATERAL DEFICITS INDUCED IN RATS BY MPP(-TERMINAL PEPTIDE FRAGMENTOF DOPAMINE-RELEASING PROTEIN() ARE MARKEDLY REDUCED BY AN N), Brain research, 666(1), 1994, pp. 117-119
Citations number
11
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
666
Issue
1
Year of publication
1994
Pages
117 - 119
Database
ISI
SICI code
0006-8993(1994)666:1<117:UDIIRB>2.0.ZU;2-I
Abstract
Dopamine-releasing protein (DARP) is a novel factor involved in the fu nction and development of catecholaminergic systems. To test whether a peptide synthesized from the N-terminus of DARP (DARP-36aa) ameliorat es deficits in nigrostriatal dopamine, rats were unilaterally lesioned with MPP(+), 1 day before administration of DARP-36aa began. Striatal delivery of 1 mu g DARP-36aa daily for 10 days elevated striatal dopa mine (P < 0.01) and reduced amphetamine-induced rotations (P < 0.05) r elative to controls, both indicating the protection or restoration of dopaminergic function.