GLUCOPYRANOSIDE-BASED SURFACTANTS AS PSEUDOSTATIONARY PHASES FOR CHIRAL SEPARATIONS IN CAPILLARY ELECTROPHORESIS

Dodecyl beta-D-glucopyranoside monophosphate and monosulfate anionic s urfactants have been synthesized and used successfully in micellar ele ctrokinetic capillary chromatography for the separation of enantiomers . These surfactants have low critical micelle concentrations of about 0.5 and 1.0 mM, respectively. The methodology developed is applicable to chiral molecules differing widely in chemical structure, hydrophobi city, and acidity. The use of these surfactants extends the usefulness of CE as a tool for chiral separations, complementary to other techni ques such as thin-layer chromatography and high-performance liquid chr omatography.