DIAGNOSTIC AND THERAPEUTIC ASPECTS OF PLA TELET-DEPENDENT HEMOSTATIC DISORDERS

Platelet-dependent bleeding disorders can cause life-threatening emerg encies. Thus it is often necessary, irrespective of the underlying dis ease, to treat the bleeding immediately. The present article reviews t he possibilities of systemic therapy of platelet-dependent bleeding di sorders. For systematisation and control of the therapeutical effect o f prednisolone, blood transfusion and injection of a phospholipid comp lex with procoagulatory activity, a bleeding model created by administ ration of aspirin was used. Investigations in thrombocytopenic patient s and dogs with aspirin-induced thrombocytopathy showed that 5 mg/kg B W prednisolone leads to a short-term hemostasis. The hemostyptic effec ts of whole blood preserves, fresh or stored for a longer period of ti me, can be increased by administration of prednisolone prior to the tr ansfusion. The use of phospholipids is not recommendable because it ha s possible risks for the patient.