We report a case of intrathyroid salivary gland tissue in a 66-year-ol
d Caucasian female with multinodular goiter. Lobules of well different
iated seromucinous salivary glands were found in close relationship wi
th car tilage and fat, and intimately associated with normal thyroid f
ollicles and solid cell nests (SCN) of the thyroid gland. This is the
first report of non-neoplastic intrathyroid salivary gland tissue. We
conclude that this heterotopic tissue probably arises from the SCN as
ultimobranchial vestigial structures.