REGULATION OF CELL-CYCLE SYNCHRONIZATION BY DECAPENTAPLEGIC DURING DROSOPHILA EYE DEVELOPMENT

Authors
PENTON A SELLECK SB HOFFMANN FM
Citation
A. Penton et al., REGULATION OF CELL-CYCLE SYNCHRONIZATION BY DECAPENTAPLEGIC DURING DROSOPHILA EYE DEVELOPMENT, Science, 275(5297), 1997, pp. 203-206
Citations number
29
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
275
Issue
5297
Year of publication
1997
Pages
203 - 206
Database
ISI
SICI code
0036-8075(1997)275:5297<203:ROCSBD>2.0.ZU;2-C
Abstract
In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-beta-related gene decapentaplegic (dpp ) was required for the synchronization of the cell cycle but not for c ell fate specification. DPP may affect cell cycle synchronization by p romoting cell cycle progression through the G(2)-M phases. This synchr onization is critical for the precise assembly of the eye.