ACTIVATION OF INTERFERON-GAMMA INDUCING FACTOR-MEDIATED BY INTERLEUKIN-1-BETA CONVERTING-ENZYME

Authors
GU Y KUIDA K TSUTSUI H KU G HSIAO K FLEMING MA HAYASHI N HIGASHINO K OKAMURA H NAKANISHI K KURIMOTO M TANIMOTO T FLAVELL RA SATO V HARDING MW LIVINGSTON DJ SU MSS
Citation
Y. Gu et al., ACTIVATION OF INTERFERON-GAMMA INDUCING FACTOR-MEDIATED BY INTERLEUKIN-1-BETA CONVERTING-ENZYME, Science, 275(5297), 1997, pp. 206-209
Citations number
33
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science → ACNP
ISSN journal
00368075
Volume
275
Issue
5297
Year of publication
1997
Pages
206 - 209
Database
ISI
SICI code
0036-8075(1997)275:5297<206:AOIIFB>2.0.ZU;2-F
Abstract
The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes t he inactive IL-IP precursor to the proinflammatory cytokine. ICE was a lso shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activa ted ICE-deficient (ICE(-/-)) Kupffer cells synthesized the IGIF precur sor but failed to process it into the active form. Interferon-gamma an d IGIF were diminished in the sera of ICE(-/-) mice exposed to Propion ibacterium acnes and lipopolysaccharide. The lack of multiple proinfla mmatory cytokines in ICE(-/-) mice may account for their protection fr om septic shock.