HYALURONIC-ACID MODULATES ACUTE AND CHRONIC INFLAMMATION

Authors
IALENTI A DIROSA M
Citation
A. Ialenti et M. Dirosa, HYALURONIC-ACID MODULATES ACUTE AND CHRONIC INFLAMMATION, Agents and actions, 43(1-2), 1994, pp. 44-47
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
43
Issue
1-2
Year of publication
1994
Pages
44 - 47
Database
ISI
SICI code
0065-4299(1994)43:1-2<44:HMAACI>2.0.ZU;2-L
Abstract
We have studied the effect of hyaluronic acid (HA) in two standard mod els of acute and chronic inflammation in the rat, i.e. carrageenin oed ema and adjuvant arthritis. Our results show that HA was able to inhib it, in a dose-related fashion, both types of inflammatory reactions. T hese findings suggest that HA may have a modulatory role in the inflam matory process and may explain, at least in part, the protective role of HA in the inflammatory cartilage damage.