NATURAL-KILLER-CELL LEUKEMIA - AN AUTOPSY CASE

We describe an autopsy case of natural killer cell leukemia. Leukemic cells appeared morphologically as large granular lymphocytes and expre ssed a restricted natural killer cell phenotype (CD2, CD38, CD56, HLA- DR). Immunogenotypic analysis revealed germline configurations of TCR- beta, TCR-gamma, and JH genes, indicating a non-T-cell or non-B-cell l ineage. These features are consistent with natural killer cell leukemi a, a recently proposed clinicopathologic entity. Autopsy findings were characterized by an extremely dense infiltration of leukemic cells in most organs, along with destruction of the normal architecture, corre sponding to an aggressive clinical course. Hemophagocytic histiocytosi s and an absence of chronic inflammatory reactions caused by recurrent infection in our case are different from morphologic features of CD3( +) large granular lymphocytic leukemia. No relationship between Epstei n-Barr virus and natural killer cell leukemia was observed.