METHOXYPSORALEN PHOTOTHERAPY OF TRANSITIONAL-CELL CARCINOMA

Citation
Te. Keane et al., METHOXYPSORALEN PHOTOTHERAPY OF TRANSITIONAL-CELL CARCINOMA, Urology, 44(6), 1994, pp. 842-846
Citations number
21
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
00904295
Volume
44
Issue
6
Year of publication
1994
Pages
842 - 846
Database
ISI
SICI code
0090-4295(1994)44:6<842:MPOTC>2.0.ZU;2-V
Abstract
Objectives. The goal of this research was to assess whether methoxypso ralen compounds in combination with ultraviolet light were effective i n preventing cellular proliferation in an in vitro model of human tran sitional cell carcinoma.Methods. Three methoxypsoralen compounds, 5-me thoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and 4'-aminomethyl 4 ,5'-8'-trimethylpsoralen (AMT), were added in vitro to T-24 transition al cell carcinoma cells. Psoralens directly bind to DNA, cross-linking the strands when exposed to ultraviolet light and thereby prevent cel lular division. Results. In vitro activity was demonstrated utilizing AMT and ultraviolet radiation at 320 to 340 nm, preventing cellular pr oliferation in T-24 transitional cell carcinoma. Conclusions. Methoxyp soralen compounds in combination with ultraviolet light are effective in preventing proliferation of bladder carcinoma cells in vitro. This therapy may prove to be effective in clinical early stage transitional cell carcinoma and warrants further assessment.