Asynchronous involvement of both testes by non-Hodgkin's lymphoma was
observed in 3 patients ranging in age from 38 to 82 years. According t
o the Working Formulation, all cases were classified as large cell imm
unoblastic lymphomas, and immunohistochemical studies demonstrated a T
-cell phenotype in 1 patient and a B-cell phenotype in 2 patients. Rel
apse to the contralateral testis occurred after a mean interval of 6 m
onths. The negative prognostic impact of these neoplasms is confirmed
in the present series, since 2 patients died of disease 7 and 9 months
after diagnosis and 1 patient had a laterocervical and Waldeyer's rin
g recurrence after 1 year.