NEURAL CELL-ADHESION MOLECULE (CD56)-POSITIVE, T(8-21) ACUTE MYELOID-LEUKEMIA (AML, M-2) AND GRANULOCYTIC SARCOMA

Authors
KRISHNAN K ROSS CW ADAMS PT PEREIRA A ROTH MS
Citation
K. Krishnan et al., NEURAL CELL-ADHESION MOLECULE (CD56)-POSITIVE, T(8-21) ACUTE MYELOID-LEUKEMIA (AML, M-2) AND GRANULOCYTIC SARCOMA, Annals of hematology, 69(6), 1994, pp. 321-323
Citations number
12
Categorie Soggetti
Hematology
Journal title
Annals of hematology → ACNP
ISSN journal
09395555
Volume
69
Issue
6
Year of publication
1994
Pages
321 - 323
Database
ISI
SICI code
0939-5555(1994)69:6<321:NCM(TA>2.0.ZU;2-Z
Abstract
A 49-year-old man with t(8; 21) acute myeloid leukemia relapsed 8 mont hs after successful induction chemotherapy with a paraspinal granulocy tic sarcoma. There was no evidence of leukemia in the bone marrow at r elapse. At initial presentation, the blasts co-expressed CD 15, CD 33, CD 34, CD 45, CD 19, and CD 56 (a neural cell-adhesion molecule). Exp ression of certain cell-adhesion molecules on leukemic blasts may dete rmine a tendency to develop extramedullary relapse. The co-expression of CD 56 may have a role in the predisposition of t(8; 21) AML to deve lop GS.