INHIBITION OF MITOCHONDRIAL ATPASE BY DICARBOPOLYBORATE, A NEW ENZYME-INHIBITOR

Polyborate anions were found to inhibit mitochondrial ATPase. Mercapto and chloro derivatives of dicarbononaborates showed full inhibition o f the enzyme activity at 0.5-0.8 mM. The inhibitory effect of dodecabo rates was lower. The inhibition was of competitive type with respect t o ATP. The inhibition of soluble F-1-ATPase indicates a direct interac tion of the polyborate anion with the catalytic part of the enzyme mol ecule.