3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .12. N-SUBSTITUTED 4-AMINO-1-(2-HYDROXY OR 2-ALKYLAIMINOETHYL)-3,5-DIPHENYL-1H-PYRAZOLES WITH LOCAL-ANESTHETIC, ANALGESIC AND PLATELET ANTIAGGREGATING ACTIVITIES

The synthesis of 4-amino-3,5-diphenyl-1 H-pyrazole-1-ethanol, as well as of their N-methyl, N-ethyl and N,N-dimethyl derivatives is describe d. A series of 1-(2-alkylaminoethyl)-3,5-diphenyl-1 H-pyrazole-4-amine s and of N-substituted 4-dimethylamino-3,5 -diphenyl-1H-pyrazole-1-eth anamines were also prepared. Some of the above compounds showed remark able local anesthetic, analgesic and in vitro platelet antiaggregating activities, as well as moderate antiinflammatory and antipyretic acti vities in rats and mice.