O-[OMEGA-(DIALKYLAMINO)ALKYL]OXIMES OF (-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-ONE WITH HYPOTENSIVE, ANTIINFLAMMATORY, ANALGESIC, LOCAL-ANESTHETIC AND OTHER ACTIVITIES())

The synthesis of(+)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one O-[omega -(dialkylamino)alkyl]oximes by reaction of(+)-camphoroxime sodium salt with a series of omega-(chloroalkyl)dialkylamines in DMF solution is described. Some of the above compounds showed strong hypotensive, anti inflammatory, analgesic and local anesthetic activity in rats and mice , as well as moderate antiarrhythmic, antipyretic and in vitro platele t antiaggregating activity.