SUBENDOMETRIAL-MYOMETRIAL CONTRACTILITY IN CONCEPTION AND NON-CONCEPTION EMBRYO-TRANSFER CYCLES

This study describes the characteristics of subendometrial-myometrial contractions seen on transvaginal sonography on the day of embryo tran sfer in assisted conception cycles and their significance for pregnanc y outcome. A total of 112 cycles were studied where three embryos with minimal or no fragmentation were transferred. Transvaginal sonography was performed just prior to embryo transfer. A sagittal view of the u terine cavity was obtained and the ultrasound probe was held steady fo r 2 min. The video recorded image was analyzed at normal, three and fi ve times normal speed. The frequency (contractions/min), direction (fu ndally or cervically directed) and length (entire cavity or localized) of contractions were noted. Conception and non-conception cycles were compared by determining the standard error of difference between mean s and proportions and the confidence intervals. The mean frequencies o f contractions in the conception and non-conception cycles were 2.09 ( SD = 0.8) and 1.92 (SD = 0.85), respectively. A total of 57.6% of cycl es in the conception group and 46% in the non-conception group had con tractions directed towards the cervix. There was no statistically sign ificant difference between the two groups in any of the parameters stu died. However, when frozen embryo replacement cycles (n = 40) were stu died separately, the incidences of fundally directed contractions were 28.6% and 66.7% in conception and non-conception cycles, respectively . This was statistically significant. Comparison of cycles resulting i n miscarriage with those leading to pregnancies beyond 16 weeks reveal ed no statistical difference in the characteristics of the contraction s. We concluded that subendometrial-myometrial contractions studied on the day of embryo transfer (luteal day 2) do not predict the outcome in in vitro fertilization cycles.