H. Brussow et al., COPROANTIBODIES TO ROTAVIRUS SEROTYPE-1 INFECTION IN GERMAN CHILDREN, Journal of diarrhoeal diseases research, 12(3), 1994, pp. 194-199
One hundred and ninety-eight serial stool samples were collected from
27 infants and children hospitalized in Bochum, Germany with gastroent
eritis due to serotype 1 rotavirus (RV). RV antigen and RV-specific an
tibodies (Ab) (IgA ELISA and RV Wa-neutralizing Ab) were measured. The
prevalence of RV-Ab positive stool samples in RV patients did not dif
fer from that in stool samples from 80 control patients (40% and 42% f
or ELISA Ab and 11% and 6% for neutralizing Ab, respectively). None of
the patients was breastfed in the week preceding stool collection. No
significant increase in the prevalence of RV-Ab was observed between
stool samples obtained during the early and late phase of hospitalizat
ion. We observed patients that continued to excrete RV antigen in the
presence of neutralizing stool activities, and patients that showed ce
ssation of RV stool excretion and resolution of clinical symptoms in t
he absence of RV-neutralizing activity in the stool samples.