Eighty-four patients with clinical findings of hyperactive rhinopathy
and no significant septal deviations were treated for 4 weeks with top
ical applications of capsaicin, which is the pungent substance in hot
peppers. A neutral solution of low-dose capsaicin allowed patients to
administer self-therapy without the need for local anesthesia. The maj
ority of the patients showed a marked reduction in symptoms without si
gnificant side effects. Patients with (additional) allergic or medicat
ion-related rhinopathy seemed to show fewer therapeutic effects when c
ompared to patients with only hyperactive rhinopathy.