STUDY-GROUP ON HUMAN SPONGIFORM ENCEPHALO PATHIES - PRELIMINARY-RESULTS

Citation
Jp. Brandel et al., STUDY-GROUP ON HUMAN SPONGIFORM ENCEPHALO PATHIES - PRELIMINARY-RESULTS, Revue neurologique, 150(10), 1994, pp. 684-688
Citations number
12
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00353787
Volume
150
Issue
10
Year of publication
1994
Pages
684 - 688
Database
ISI
SICI code
0035-3787(1994)150:10<684:SOHSEP>2.0.ZU;2-L
Abstract
Several French teams including clinicians and researchers have created a group within the European network for the study of Creutzfeldt-Jako b disease and other human spongiform encephalopathies. The main object ies are to monitor the incidence of the disease and to search for poss ible risk factors with a case-control study. The diagnosis is based on neuropathological studies or rite identification of an abnormal prote in prion in cerebral fragments. The sequence of the gene encoding for the prion protein has was studied from blood or cerebral samples. The early results indicate that the incidence, mortality and clinical pres entation remain relatively constant compared with earlier studies. Stu dying the expression of the 129 codon of the prion protein gene has le d to the verification that homozygous methionine/methonine forms predo minate in sporadic forms.