CHANGES IN THE ACTIVITY OF NADH-OXIDASE IN RAT-TISSUES DURING EXPERIMENTAL DIABETES

Authors
ASKAR MA BAQUER NZ
Citation
Ma. Askar et Nz. Baquer, CHANGES IN THE ACTIVITY OF NADH-OXIDASE IN RAT-TISSUES DURING EXPERIMENTAL DIABETES, Biochemistry and molecular biology international, 34(5), 1994, pp. 909-914
Citations number
18
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
34
Issue
5
Year of publication
1994
Pages
909 - 914
Database
ISI
SICI code
1039-9712(1994)34:5<909:CITAON>2.0.ZU;2-P
Abstract
The effects of alloxan diabetes and its reversal with insulin treatmen t, on NADH-oxidase (E.C.1.6.99.3) was measured in the microsomal fract ions of brain, liver and kidney at different time interval after diabe tes induction. A significant increase was found in the enzyme activity in brain and kidney microsomes of the diabetic animals, whereas liver showed a decrease. The decrease in the NAD(+)/NADH ratio in the diabe tes reported earlier could be due to the changes in the enzyme activit y as well as other changes in the metabolite. concentration.