Nv. Kondakova et al., RADIATION-INDUCED CHEMICAL-TRANSFORMATIONS OF HUMAN SERUM-ALBUMIN IN AQUEOUS-SOLUTIONS, High energy chemistry, 28(6), 1994, pp. 439-445
A rate constant of the reaction of human serum albumin (HSA) with OH r
adicals was determined using the method of competing scavengers. Chang
es in the amino acid composition and some biochemical properties of HS
A on radiolysis in a berate buffer (pH 7.4) saturated with N2O or O-2
were correlated quantitatively. It was found that the yield of peptide
bonds that lost the ability to be cleaved by trypsin is higher than t
he total yield of arginine and lysine residues in HSA. The possibility
of accumulation of modified HSA in blood upon irradiation was conside
red.