PEPTIDE BACKBONE-TO-BACKBONE CYCLIZATION AS AN AVENUE TO BETA-TURN MIMICS

Authors
HERMKENS PHH VONDINTHER TG JOUKEMA CW WAGENAARS GN OTTENHEIJM HCJ
Citation
Phh. Hermkens et al., PEPTIDE BACKBONE-TO-BACKBONE CYCLIZATION AS AN AVENUE TO BETA-TURN MIMICS, Tetrahedron letters, 35(49), 1994, pp. 9271-9274
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
49
Year of publication
1994
Pages
9271 - 9274
Database
ISI
SICI code
0040-4039(1994)35:49<9271:PBCAAA>2.0.ZU;2-3
Abstract
1,3-Dipolar cycloaddition of the nitrone functionality of 13 and the a lkene functionality of 8 yields the backbone-to-backbone cyclised pept ides 14-16. The conformation of these structures is such that they are beta-turn mimics. They differ in their C3/C5 stereochemistry with dis crete conformational differences.