A ONE-POT SYNTHESIS OF NITROHYDROXYLATED PYRROLIDINE AND PIPERIDINE RING-SYSTEMS BY TANDEM MICHAEL-HENRY REACTION

Authors
BARCO A BENETTI S DERISI C POLLINI GP ROMAGNOLI R ZANIRATO V
Citation
A. Barco et al., A ONE-POT SYNTHESIS OF NITROHYDROXYLATED PYRROLIDINE AND PIPERIDINE RING-SYSTEMS BY TANDEM MICHAEL-HENRY REACTION, Tetrahedron letters, 35(49), 1994, pp. 9293-9296
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
49
Year of publication
1994
Pages
9293 - 9296
Database
ISI
SICI code
0040-4039(1994)35:49<9293:AOSONP>2.0.ZU;2-3
Abstract
Nitrohydroxylated pyrrolidine and piperidine ring systems are convenie ntly obtained through a one-pot procedure involving sequential Michael -Henry reaction between nitroethylene and a nitrogen nucleophile incor porating a suitably placed precursor for the generation either reducti vely or oxidatively of an aldehyde group which is directly trapped in the subsequent nitroaldolization step.