SERUM IGE AND HUMAN-IMMUNODEFICIENCY-VIRU S (HIV) INFECTION

Except for Ig E, serum immunoglobulin abnormalities in persons with hu man immunodeficiency virus (HIV) infection have been well described. S erum IgE levels have been shown to rise with progressive disease. The authors evaluated IgE in 148 HIV-seropositive individuals with or with out acquired immunodeficiency syndrome (AIDS). Mean serum IgE levels w ere compared between groups based on absolute CD4 lymphocyte counts or clinical status (CDC) and with a seronegative control group. Higher s erum IgE levels were observed in seropositive-patients, A rise in IgE serum is common in patients with HIV infection; it could be link with an earlier dysregulation in the IgE synthesis, No correlation was foun d between IgE level and CD4 counts.