SELECTIVE C-2 AND C-4 DEACYLATION AND ACYLATION OF TAXOL - THE FIRST SYNTHESIS OF A C-4 SUBSTITUTED TAXOL ANALOG

Authors
GEORG GI ALI SM BOGE TC DATTA A FALBORG L HIMES RH
Citation
Gi. Georg et al., SELECTIVE C-2 AND C-4 DEACYLATION AND ACYLATION OF TAXOL - THE FIRST SYNTHESIS OF A C-4 SUBSTITUTED TAXOL ANALOG, Tetrahedron letters, 35(48), 1994, pp. 8931-8934
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
48
Year of publication
1994
Pages
8931 - 8934
Database
ISI
SICI code
0040-4039(1994)35:48<8931:SCACDA>2.0.ZU;2-1
Abstract
Hydrolytic procedures for selective 2-debenzoylation and 2,4-dideacyla tion of 0-tert-butyldimethylsilyl-7-0-(triethylsilyl)taxol are reporte d. The first synthesis and biological evaluation of a 4-substituted an alogue, 4-deacetyl-4-isobutanoyltaxol, is presented. The chemistry des cribed in this letter is suitable for the facile synthesis of taxol co ngeners modified at C-2 and/or C-4.