HIGHER-CARBON SUGARS BY ENZYMATIC CHAIN EXTENSION OXIDATIVE GENERATION OF ALDOL PRECURSORS IN-SITU

Authors
EYRISCH O KELLER M FESSNER WD
Citation
O. Eyrisch et al., HIGHER-CARBON SUGARS BY ENZYMATIC CHAIN EXTENSION OXIDATIVE GENERATION OF ALDOL PRECURSORS IN-SITU, Tetrahedron letters, 35(48), 1994, pp. 9013-9016
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
48
Year of publication
1994
Pages
9013 - 9016
Database
ISI
SICI code
0040-4039(1994)35:48<9013:HSBECE>2.0.ZU;2-U
Abstract
A novel multienzymatic approach for the preparation of complex carbohy drates by enzymic aldolization is presented in which both the aldol do nor and acceptor components are generated in situ by air oxidation usi ng microbial oxidases. The L-threo stereochemistry generated by the re combinant rhamnulose 1-phosphate aldolase has been established by X-ra y structural analysis.