STUDIES ON A POTENTIALLY PREBIOTIC SYNTHESIS OF RNA

Authors
SUTHERLAND JD WEAVER GW
Citation
Jd. Sutherland et Gw. Weaver, STUDIES ON A POTENTIALLY PREBIOTIC SYNTHESIS OF RNA, Tetrahedron letters, 35(48), 1994, pp. 9105-9108
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
48
Year of publication
1994
Pages
9105 - 9108
Database
ISI
SICI code
0040-4039(1994)35:48<9105:SOAPPS>2.0.ZU;2-I
Abstract
A novel, potentially prebiotic synthesis of RNA is proposed in which t he key steps are an aldol mode of polymerisation, intramolecular redox transfer and ring closure via a mesomeric heterocyclic betaine interm ediate. The key monomers tn this scheme are derivable, in theory, from the presumed prebiotic compound, bis(glycoaldehyde) phosphodiester 1 via its mono-formaldehyde aldol adduct 2.