Intuition and previous results suggest that a peristaltic wave tends t
o drive the mean flow in the direction of wave propagation. New theore
tical results indicate that, when the viscosity of the transported flu
id is shear-dependent, the direction of mean flow can oppose the direc
tion of wave propagation even in the presence of a zero or favourable
mean pressure gradient. The theory is based on an analysis of lubricat
ion-type flow through an infinitely long, axisymmetric tube subjected
to a periodic train of transverse waves. Sample calculations for a she
ar-thinning fluid illustrate that, for a given waveform, the sense of
the mean flow can depend on the theology of the fluid, and that the me
an flow rate need not increase monotonically with wave speed and occlu
sion. We also show that, in the absence of a mean pressure gradient, p
ositive mean flow is assured only for Newtonian fluids; any deviation
from Newtonian behaviour allows one to find at least one non-trivial w
aveform for which the mean flow rate is zero or negative. Introduction
of a class of waves dominated by long, straight sections facilitates
the proof of this result and provides a simple tool for understanding
Viscous effects in peristaltic pumping.