Depressive illness places an enormous economic burden on health servic
es, the community and the individual patient. It is a serious medical
disorder associated with high levels of social and physical disability
. Antidepressant drug therapy can produce significant improvement in t
he majority of patients. However, despite its high prevalence depressi
ve illness is frequently undetected, misdiagnosed or inappropriately t
reated. The selection of a cost-effective antidepressant requires a br
oad evaluation of the risks, costs and benefits. A choice should not b
e made on prescription drug costs alone but on the basis of the overal
l value a treatment option offers in the management of illness. Benefi
ts, such as improved treatment compliance, reduced toxicity in overdos
e, long-term safety and efficacy in the prevention of relapse and recu
rrence of depression, improved patient quality of life and decreased a
ccident liability all have cost implications which must be considered
when determining the relative cost of medication.