CORRELATION BETWEEN PROLACTIN RESPONSE AND THERAPEUTIC EFFECTS OF ZOTEPINE IN SCHIZOPHRENIC-PATIENTS

Authors
OTANI K KONDO T KANEKO S ISHIDA M FUKUSHIMA Y
Citation
K. Otani et al., CORRELATION BETWEEN PROLACTIN RESPONSE AND THERAPEUTIC EFFECTS OF ZOTEPINE IN SCHIZOPHRENIC-PATIENTS, International clinical psychopharmacology, 9(4), 1994, pp. 287-289
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International clinical psychopharmacology → ACNP
ISSN journal
02681315
Volume
9
Issue
4
Year of publication
1994
Pages
287 - 289
Database
ISI
SICI code
0268-1315(1994)9:4<287:CBPRAT>2.0.ZU;2-9
Abstract
The correlation between prolactin response and therapeutic effects of zotepine, as assessed by the Brief Psychiatric Rating Scale, was studi ed in 24 schizophrenic patients (12 males, 12 females), after 4 weeks of treatment. The daily dose was 100 mg in the first week, and 200 mg for the next 3 weeks. There were significant (p < 0.05) positive corre lations between changes in serum prolactin concentration and ameliorat ion scores of positive or total symptoms in males only. Thus, prolacti n response may reflect therapeutic effects of zotepine, at least in ma les.