ROLE OF ANTIBODIES AGAINST FIBRONECTIN-BINDING, COLLAGEN-BINDING PROTEINS AND ALPHATOXIN IN EXPERIMENTAL STAPHYLOCOCCUS-AUREUS PERITONITIS AND SEPTICEMIA IN NEUTROPENIC MICE

Authors
ROZALSKA B WADSTROM T
Citation
B. Rozalska et T. Wadstrom, ROLE OF ANTIBODIES AGAINST FIBRONECTIN-BINDING, COLLAGEN-BINDING PROTEINS AND ALPHATOXIN IN EXPERIMENTAL STAPHYLOCOCCUS-AUREUS PERITONITIS AND SEPTICEMIA IN NEUTROPENIC MICE, Zentralblatt fur Bakteriologie, 281(4), 1994, pp. 495-501
Citations number
17
Categorie Soggetti
Microbiology,Virology
Journal title
Zentralblatt fur Bakteriologie → ACNP
ISSN journal
09348840
Volume
281
Issue
4
Year of publication
1994
Pages
495 - 501
Database
ISI
SICI code
0934-8840(1994)281:4<495:ROAAFC>2.0.ZU;2-5
Abstract
We have investigated the protective role of hyperimmune rabbit IgG aga inst two surface structures of Staphylococcus aureus, i.e. fibronectin -, and collagen-binding proteins as well as alpha-toxin in experimenta l peritonitis and septicaemia in neutropenic mice pretreated with cycl ophosphamide. This treatment markedly decreased clearance of bacteria from mouse organs. With combined immunotherapy given passively bacteri a were eradicated more efficiently for all animals sampled, comparativ e to controls.